Identifying Key Genes of Liver Cancer by Using Random Forest Classification

Adeel Ashraf, Muhammad Sohaib Roomi, Muhammad Sohaib Akram

Abstract


Liver cancer is considered as one of the most deadly cancer. To devise a treatment which is helpful to eradicate, it is inevitable to identify potential biomarkers which are very important in the development of liver cancer. To identify the pathways and key genes we use different enrichment analysis techniques such as pathway analysis and functional analysis. To identify biomarkers we constructed a network which is named as protein protein interaction network to analyse by selecting different network nodes. Our results show that we identified those biomarkers like ESR1 and TOP2 successfully which are potential biomarkers for liver cancer. In addition to that our method can be applied to other different datasets which are for different diseases to choose key genes.


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References


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DOI: http://dx.doi.org/10.21015/vtse.v9i1.745

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