Generating synthetic data in biomedical imaging by designing GANs

Authors

DOI:

https://doi.org/10.21015/vtse.v12i3.1853

Abstract

Recent advances in deep learning techniques have made medical analysis available with enhanced accuracy and efficiency, where brain tumor classification is automatically identified in an influential role. Hence, one of the synthesized approaches of an innovative idea to use GANs in this paper development is the synthesis of T1-weighted and post-contrast ischemic stroke brain MRIs to increase performance in the classification of the mentioned diseases according to deep learning. This paper, therefore, has the following objective: to evaluate the efficiency of GAN-generated images in learning deep in the transfer learning models and the performance in both tumor and non-tumor brain images. We use the two main architectures of GAN in our process: Vanilla and Deep Convolutional GAN (DCGAN). Details of the three major deep transfer learning models below portray the Convolutional Neural Network (CNN), MobileNetV2, and ResNet152v2. This learned weight would become a pre-trained representation of the models combined with the augmented dataset for feature extraction and classification purposes. I.e., where transfer learning is applied in the models, it is way more accessible for those architectures of the neural network to tap into the knowledge learned by the former from large-scale datasets and adapt it for tasks at hand on classifying brain tumors. Concerning training and validation, Python programming language integrated with the Keras deep learning framework was employed to implement the indicated operations. In terms of training, GPU processing power was available to allow the model to learn faster. In this regard, this was incorporated with the GPU processing by using the NVIDIA GeForce RTX 2060 GPU. Both Vanilla GAN and DCGAN have counterparts when generating images.

References

A. Alnemer and J. Rasheed, "An Efficient Transfer Learning-based Model for Classification of Brain Tumor," in *Proc. 2021 5th International Symposium on Multidisciplinary Studies and Innovative Technologies (ISMSIT)*, Ankara, Turkey, 2021, pp. 478-482, doi: 10.1109/ISMSIT52890.2021.9604677.

C. Sun, "CNN Models Applied in Brain Cancer Diagnosis," in *Proc. 2021 2nd International Seminar on Artificial Intelligence, Networking and Information Technology (AINIT)*, Shanghai, China, 2021, pp. 289-293, doi: 10.1109/AINIT54228.2021.00064.

L. Gonzalez-Abril, C. Angulo, J.-A. Ortega, and J.-L. Lopez-Guerra, "Generative Adversarial Networks for Anonymized Healthcare of Lung Cancer Patients," *Electronics*, vol. 10, no. 2220, 2021, doi: 10.3390/electronics101822.

H. M. Rai, K. Chatterjee, A. Gupta, and A. Dubey, "A Novel Deep CNN Model for Classification of Brain Tumor from MR Images," in *Proc. 2020 IEEE 1st International Conference for Convergence in Engineering (ICCE)*, Kolkata, India, 2020, pp. 134-138, doi: 10.1109/ICCE50343.2020.9290740.

H. J. Hwang, H. Kim, J. B. Seo, J. C. Ye, G. Oh, and S. M. Lee, "Generative Adversarial Network-Based Image Conversion Among Different Computed Tomography Protocols and Vendors: Effects on Accuracy and Variability in Quantifying Regional Disease Patterns of Interstitial Lung Disease," *Korean J. Radiol.*, vol. 24, no. 8, pp. 807-820, 2023, doi: 10.3348/kjr.2023.0088.

J. Zhu, "Automatic Brain Tumor Classification Based on Transfer Learning Models," in *Proc. 2022 International Symposium on Advances in Informatics, Electronics and Education (ISAIEE)*, Frankfurt, Germany, 2022, pp. 5-8, doi: 10.1109/ISAIEE57420.2022.00009.

K. N. Guy-Fernand, J. Zhao, F. M. Sabuni, and J. Wang, "Classification of Brain Tumor Leveraging Goal-Driven Visual Attention with the Support of Transfer Learning," in *Proc. 2020 Information Communication Technologies Conference (ICTC)*, Nanjing, China, 2020, pp. 328-332, doi: 10.1109/ICTC.2020.9246819.

K. T. Chui, B. B. Gupta, R. H. Jhaveri, H. R. Chi, V. Arya, A. Almomani, and A. Nauman, "Multiround Transfer Learning and Modified Generative Adversarial Network for Lung Cancer Detection," *IEEE Access*, vol. 9, pp. 153535-153545, 2022, doi: 10.1109/ACCESS.2020.3017915.

C.-H. Lin, C.-J. Lin, Y.-C. Li, and S.-H. Wang, "Generative Adversarial Networks and Parameter Optimization of Convolutional Neural Networks for Lung Tumor Classification," *Applied Sciences*, vol. 11, no. 480, 2021, doi: 10.3390/app11020480.

U. Wijerathna, N. Dissanayake, D. Nimasha, U. Senarathne, L. Weerasinghe, and C. Kahandawaarachchi, "Brain Tumor Detection Using Image Processing," in *Proc. 2023 5th International Conference on Advancements in Computing (ICAC)*, Colombo, Sri Lanka, 2023, pp. 733-738, doi: 10.1109/ICAC60630.2023.10417291.

M. Mondal, M. F. Faruk, N. Raihan, and P. Ahammed, "Deep Transfer Learning Based Multi-Class Brain Tumors Classification Using MRI Images," in *Proc. 2021 3rd International Conference on Electrical & Electronic Engineering (ICEEE)*, Rajshahi, Bangladesh, 2021, pp. 73-76, doi: 10.1109/ICEEE54059.2021.9719003.

M. Y. Mehemud, H. Binte Kibria, and A. Salam, "Efficient Brain Tumor Classification through Transfer Learning Models," in *Proc. 2023 26th International Conference on Computer and Information Technology (ICCIT)*, Cox’s Bazar, Bangladesh, 2023, pp. 1-6, doi: 10.1109/ICCIT60459.2023.10441144.

F. Munawar, S. Azmat, T. Iqbal, C. Gronlund, and H. Ali, "Segmentation of Lungs in Chest X-Ray Image Using Generative Adversarial Networks," *IEEE Access*, vol. 8, pp. 153535-153545, 2020, doi: 10.1109/ACCESS.2020.3017915.

M. Nishio, K. Fujimoto, H. Matsuo, C. Muramatsu, R. Sakamoto, and H. Fujita, "Lung Cancer Segmentation With Transfer Learning: Usefulness of a Pretrained Model Constructed From an Artificial Dataset Generated Using a Generative Adversarial Network," *Front. Artif. Intell.*, vol. 4, 2021, doi: 10.3389/frai.2021.694815.

P. S. Ramapraba, P. Epsiba, K. Umapathy, and E. Sivanantham, "Auxiliary Classifier of Generative Adversarial Network for Lung Cancer Diagnosis," *IEEE Access*, 2022, note: Received: May 4, 2022; Accepted: Jun 15, 2022.

R. Pillai, A. Sharma, N. Sharma, and R. Gupta, "Brain Tumor Classification using VGG 16, ResNet50, and Inception V3 Transfer Learning Models," in *Proc. 2023 2nd International Conference for Innovation in Technology (INOCON)*, Bangalore, India, 2023, pp. 1-5, doi: 10.1109/INOCON57975.2023.10101252.

S. Ellis, "Evaluation of 3D GANs for Lung Tissue Modelling in Pulmonary CT," *School of Biomedical Engineering and Imaging Sciences, King’s College London, UK*, 2022, note: Submitted 12/2021; Published 08/2022.

S. R. Rezaei and A. Ahmadi, "A GAN-based method for 3D lung tumor reconstruction boosted by a knowledge transfer approach," *IEEE Access*, 2023, note: Received: May 5, 2022 / Revised: Feb 18, 2023 / Accepted: Mar 30, 2023.

U. Wijerathna, N. Dissanayake, D. Nimasha, U. Senarathne, L. Weerasinghe, and C. Kahandawaarachchi, "Brain Tumor Detection Using Image Processing," in *Proc. 2023 5th International Conference on Advancements in Computing (ICAC)*, Colombo, Sri Lanka, 2023, pp. 733-738, doi: 10.1109/ICAC60630.2023.10417291.

```

Downloads

Published

2024-08-21

How to Cite

Awan, T., Mushtaq, M. D., Shahzad, M. A., Ghani, U., Muhammad Tariq, & Noon, S. K. (2024). Generating synthetic data in biomedical imaging by designing GANs. VFAST Transactions on Software Engineering, 12(3), 44–54. https://doi.org/10.21015/vtse.v12i3.1853