Promising Compounds for Treatment of Covid-19
DOI:
https://doi.org/10.21015/vtcs.v1i1.555Abstract
The study spans over-identification of phytochemicals suited for the treatment of COVID-19. The study focuses on the chemical that has a tendency to bind with Human ACE2 protein and two of the main Sars-Cov-2 proteins which are the Spike protein and the RNA-directed RNA polymerase (RdRp) protein. After screening a large list of phytochemicals two of the compound i.e. Kansuinine B and Digitoxin were found to have promising traits for the treatment of COVID-19. Both the compounds have been in use for centuries. Digitoxin was extracted from Foxglove seeds in the 18th century for heart-related illnesses. Kansuinine B originates from a Chinese herb Euphorbia Kansui (E. Kansui) E. Kansui has been widely used in herbal medicine for a multitude of illnesses including lungs related diseases. Studies also show that it has the ability to suppress cytokine response through the expression of the SOCS3 gene. In-silico simulations show that both these compounds have a better affinity and binding properties with these three proteins as compared to many other drugs under trial for COVID-19 like Remdesivir, Ritonavir, Famotidine, Camostat Mesylate, and Hesperidin. A treatment based on the combination of both compounds can be very effective. Any self-medication of both the compounds is highly discouraged as misuse of both the compounds can be very harmful.References
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